The Neural Circuits For Movement Laboratory Ucl Cover Letter
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Research Assistant Cover Letter At THE NEURAL CIRCUITS FOR MOVEMENT LABORATORY UCL
THE NEURAL CIRCUITS FOR MOVEMENT LABORATORY UCL
Education Uskudar University
M.Sc. September 2019-June
2022 Istanbul
Turkey Cumulative GPA:3.78 High Honor Student Master Science in Neuroscience Department of Neuroscience Sciences Thesis: Investigation of TopoII ß Gene Expression in LPS-Induced HMC3 Microglia Cell Line Pamukkale University
B.Sc. September2015-June 2019 Denizli
Turkey Cumulative GPA: 3.0 Honour Student Bachelor of Science in Physical Therapy and Rehabilitation Universitat de Barcelona September2018- June 2019 Barcelona
Spain International Student ERASMUS Study Abroad Program Skills & Qualifications • Ability to work independently and efficiently. • Strong organizational and task prioritization skills. • Excellent communication skills and proficiency in performing administrative and clerical tasks. • Proficient in general laboratory procedures
techniques
and documentation. • Willingness to learn and adapt to new techniques and technologies. • Fluent in English
Spanish
French
and Catalan. • Proficient in statistical analysis and software such as SPSS
MATLAB
and Python. • Proficient in using various software programs
including Microsoft Office Suite (Word
Excel
PowerPoint). • Advanced knowledge and experience in 3D cell culture techniques. • Skilled in protein isolation
Western Blot
PCR
rt-qPCR
toxicity testing
IHC
Northern Blot
and ELISA. • Proficient in anatomical dissection studies for medical and veterinary purposes. • Experienced in static analysis of behavioral data and microarray data. • Familiarity with electrophysiology
imaging
protein purification
and optical and electron microscopy techniques. • Advanced level proficiency in conducting animal experiments
behavioral experiments
anatomical dissection
and molecular analysis. Stem Cells We derive motor neurons from stem cells to study activity patterns in culture conditions (for example
when cultured with different types of cells)
as well as to use for transplantation experiments to reinnervate muscle fibres. Spino-muscular circuits The spinal cord contains motor neurons - the nerve cells that connect with muscles controlling their contraction. We study how the nervous system ensures that the electrical signals in these motor neurons are controlled in order to produce the required amount of muscle contraction. In addition
motor neurons die in motoneuron diseases (MNDs) such as amyotrophic lateral sclerosis (ALS). We study impairments in motor neuron circuits in models of MNDs Spinal cord circuits We focus on two core organisational circuits in the spinal cord: those producing locomotor activity
and those important for regulating hand grasp. We are particularly interested in how these circuits discriminate unexpected sensory input from the sensory input that the movement is expected to produce. Circuitopathies Many neurological diseases lead to impairment of movement. We use a number of models in the lab to study the circuits involved in this movement dysregulation. For example
one circuitopathy that we are studying leads to dystonia.Brain stem - spinal cord circuits The ponto-medullary reticular formation is home to reticulospinal neurons. We have focussed on a region called the gigantocellular reticular nucleus (GRN) to identify how circuits in this region are wired and how activity of identified GRN neurons is related to locomotion.Research Projects Our work in the lab focuses on brain stem
spinal cord
and spino-muscular circuits. We use a number of approaches spanning ion channel physiology to behavioural assays to define these circuits. Return to homepage Our goal In many neurological diseases
quality of life is impaired due to disruptions to normal movement. We investigate how normal movement is produced by neural circuits
and how disruption to these circuits in disease impairs movement. Our goal is to lay foundations for new strategies aimed at improving movement in people with neurological diseases. Neural Circuits for Movement To understand circuits
we loosely think of forebrain circuits as those responsible for movement selection. These circuits inform brain stem circuits which produce the “commands” needed to accomplish the movement. Brain stem circuits in turn project to spinal cord organisation circuits: the spinal cord determines the sequence and timing of muscle contraction needed for the movement at hand. And finally
spino-muscular circuits between the spinal cord and muscles ensure that the amount of muscle contraction is appropriate for the task. The communications between the circuits is bi-directional: spino-muscular circuits inform spinal cord circuits which inform the brain stem
and the brain stem informs the forebrain. In addition
the cerebellum processes information from these motor circuits and then modifies them - for example
to assist with smooth movements. Not all of these circuits are necessary for all movements: there are instances
for example
where the forebrain informs spinal cord circuits directly. The Neural Circuits for Movement Laboratory While treatments of neurological diseases have progressed remarkably well in the relative absence of detailed knowledge of either the mechanisms of diseases or the mechanisms of action of treatments
knowledge of both of these inter-dependent mechanisms will lead to new treatments with improved safety and the effectiveness. We aim to understand how the brain and spinal cord work together to ensure that the intended movement accomplishes the task at hand. Furthermore
we study how these motor circuits are affected by neurological conditions
with the aim of developing strategies so that the function of these circuits can be restored so as to improve quality of life. We combine electrophysiological and imaging techniques with mouse genetics to understand motor circuits
with a goal of developing new strategies to improve movement in neurological disease or following injury
By Melike Cansel EREN
Melike Cansel EREN
[Your Address]
[City, State ZIP Code]
[Email Address]
[Today’s Date]
Prof R. Brownstone
The Neural Circuits for Movement Laboratory UCL
[Address]
[City, State ZIP Code]
Dear Prof. Brownstone,
I am writing to express my enthusiasm and interest in the Research Assistant position at The Neural Circuits for Movement Laboratory UCL. As a highly motivated and dedicated individual with a strong passion for neuroscience and a diverse background in research and laboratory techniques, I am confident that I possess the necessary skills and qualifications to excel in this role.
Firstly, let me introduce myself. My name is Melike Cansel EREN and I am currently a Master's student in Neuroscience at Uskudar University in Istanbul, Turkey. My education has provided me with a solid foundation in the field of neuroscience and has equipped me with a comprehensive understanding of the principles and techniques involved in research. I am also an honor student with a cumulative GPA of 3.78, which reflects my dedication and commitment to academic excellence.
I was particularly drawn to The Neural Circuits for Movement Laboratory due to its cutting-edge research and its focus on studying motor circuits in relation to neurological diseases. I am fascinated by the work being done in your lab and I strongly believe that my skills and interests align perfectly with the goals of your laboratory. I am particularly interested in your research projects on brain stem, spinal cord, and spino-muscular circuits and how they contribute to normal movement and are affected by neurological conditions. Your lab's goal of improving the quality of life for those with neurological diseases through understanding and restoring motor circuits is truly inspiring to me.
In terms of my skills and qualifications, I possess a diverse range of research experience and laboratory skills. My Master's thesis, which focused on investigating the expression of TopoII ß gene in LPS-induced HMC3 microglia cell line, honed my skills in molecular biology techniques such as Western Blot, PCR, rt-qPCR, and ELISA. Additionally, my time at Pamukkale University as a Bachelor's student in Physical Therapy and Rehabilitation has provided me with a strong understanding of anatomical dissection techniques for medical and veterinary purposes.
Furthermore, my experience as an international student at Universitat de Barcelona during my Erasmus Study Abroad Program has enhanced my communication skills and has made me fluent in English, Spanish, French, and Catalan. This has also given me the opportunity to adapt to new cultures and work with diverse teams, making me an excellent fit for the collaborative environment at your lab.
I am also proficient in using various software programs, including Microsoft Office Suite, and have experience in statistical analysis with software such as SPSS, MATLAB, and Python. My advanced knowledge and experience in 3D cell culture techniques and protein isolation, as well as my familiarity with electrophysiology, imaging, and microscopy techniques, make me well-suited for the research projects at your lab.
Moreover, I have a strong ability to work independently and efficiently, with excellent organizational and task prioritization skills. I am a quick learner and always willing to adapt to new techniques and technologies. I am confident that my skills and qualifications make me a strong candidate for the Research Assistant position at The Neural Circuits for Movement Laboratory.
In addition to my academic and research experience, I am also passionate about giving back to the community. I have volunteered at various organizations, including a local rehabilitation center, where I assisted in conducting behavioral experiments and analyzing data. This experience has further developed my skills in data analysis and my understanding of the impact of neurological diseases on individuals and their families.
In conclusion, I am thrilled at the opportunity to contribute to the groundbreaking research being done at The Neural Circuits for Movement Laboratory. I am confident that my skills and passion for neuroscience make me a perfect fit for this position. Thank you for considering my application. I look forward to discussing my qualifications further with you.
Sincerely,
Melike Cansel EREN